Hashem Taha (MASc): Assessing the immunomodulatory effects of Ganoderma lucidum on the cancer killing capacity of natural killer cells

September 20, 2017 @ 9:00 am – 9:30 am
Rosebrugh Building
Rosebrugh Bldg, Toronto, ON M5S 3G9

Room: RS 211


Ganoderma lucidum (G. lucidum) is a medicinal fungus showing a variety of biological functional activities, and has being used for millennia as a folk remedy for promotion of health and longevity. One of the most attractive characters of G. lucidum is its diverse immune-modulatory activity. These phenomena suggest G. lucidum may contain different active components that can be prepared from different extraction methods with distinguished immune-modulatory activity. Using NK-92, a natural killer (NK) cell line, as the study model, we set out to evaluate the effect of three G. lucidum extracts on NK cell activity. NK-92 cells pretreated with aqueous G.lucidum extracts demonstrate enhanced cytotoxicity against a panel of tumor targets in vitro in a dose dependent manner. Results from these studies indicate the presence of bioactive components in the aqueous extract that have stimulatory immune-modulation activities. Further studies will aim at purification and characterization of these active components from both G.lucidum aqueous extracts.