160 College St
Toronto, ON M5S 3E2
Modelling the neurovascular unit with human pluripotent stem cells
Sean Palecek, Professor
Department of Chemical & Biological Engineering
University of Wisconsin-Madison
Host: Zandstra Lab for Stem Cell Bioengineering
About the Palecek Lab
We are interested in characterizing the nature in which quantitative changes in the flow of cellular signals can control a wide variety of useful processes and will design strategies to stimulate or inhibit cellular signaling pathways, either at the chemical or physical level, and thereby regulate cell functions.
We focus on differentiating keratinocytes, skin cells and cardiomyocytes, heart muscle cells from hPSCs. We are also investigating the Wnt pathway in hPSCs seeded onto 3D constructs.
Our group is also investigating microfluidic devices to design a high throughput protein array for cancer diagnosis. We aim to immobilize substrates for breast cancer kinases in order to detect the overactive kinases present in a cell lysate. This will help patient specific therapy by determining which kinase inhibitors are most effective for which patients.