Warren C. W. Chan

Warren Chan

Warren Chan | Distinguished Professor of Nanobioengineering
BSc (U of Illinois-Urbana Champaign), PhD (Indiana University)

Main Appointments

  • Institute of Biomaterials & Biomedical Engineering

Additional Appointments

  • Department of Chemical Engineering & Applied Chemistry
  • Department of Chemistry
  • Department of Materials Science & Engineering
  • Donnelly Centre for Cellular & Biomolecular Research

Contact Information

Office: Donnelly Centre, 160 College Street, Room 402

+1 416 946-8416 (office)
warren.chan@utoronto.ca (email)
Integrated Nanotechnology & Biomedical Sciences Laboratory (web)

Research Theme

Nanotechnology, Molecular Imaging & Systems Biology

Research Interests

The Chan research group is currently interested in studying and understanding  the proteomic and genomic changes associated with abnormal cells (e.g., cancer cells or virally-infected cells) and tissues. We aim to elucidate the cell’s molecular dynamics by using recent developments in nanotechnology (e.g., inorganic nanostructures), microtechnology (e.g., micro-electromechanical systems and capillary flow systems), and molecular engineering (e.g., phage-display) as well as engineering new instrumentation and techniques to address biological questions. A fundamental understanding of molecular processes with technology developments should lead to the design of novel diagnostic schemes and therapeutic strategies.

Select Publications

Are Quantum Dots Toxic? Exploring the Discrepancy Between Cell Culture and Animal Studies. Tsoi KM, Dai Q, Alman BA, Chan WC.  Acc Chem Res. 2012 Aug 1.

Nonblinking Plasmonic Quantum Dot Assemblies for Multiplex Biological Detection. Song F, Tang PS, Durst H, Cramb DT, Chan WC.  Angew Chem Int Ed Engl. 2012 Jul 29.

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems. Albanese A, Tang PS, Chan WC.  Annu Rev Biomed Eng.

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. Walkey CD, Chan WC.  Chem Soc Rev. 2012 Apr 7. 41(7):2780-99.

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. Walkey CD, Olsen JB, Guo H, Emili A, Chan WC.  J Am Chem Soc. 2012 Feb. 1134(4):2139-47.

Principles of conjugating quantum dots to proteins via carbodiimide chemistry. Song F, Chan WC.  Nanotechnology. 2011 Dec 9. 22(49):494006.

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