Hai-Ling Margaret Cheng

Hai-Ling Margaret Cheng

Hai-Ling Margaret Cheng | Assistant Professor
BSc (Calgary), MSc (Calgary), PhD (Toronto), PEng

Main Appointments

  • Institute of Biomaterials & Biomedical Engineering
  • Edward S. Rogers Sr. Department of Electrical & Computer Engineering

Additional Appointments

  • Leslie Dan Faculty of Pharmacy
  • Adjunct Scientist, Physiology & Experimental Medicine, Hospital for Sick Children

Contact Information

Translational Biology & Engineering Program
Ted Rogers Centre for Heart Research
MaRS West Tower, 661 University Ave, Room 1433-N (14th floor)
Toronto, Ontario M5G 1M1 Canada

+1 416 978-4095 (office)
hailing.cheng@utoronto.ca (email)
Cheng Lab (web)

Research Theme

Research Interests

  • Non-invasive magnetic resonance imaging (MRI) for cellular, molecular, and physiological imaging
  • New contrast agents for vascular and cellular imaging and targeting
  • Quantitative MRI methods to measure microvascular function
  • Monitoring vascularization and regeneration in tissue-engineered systems
  • Early cancer detection and diagnosis

Select Publications

Loai S, Haedicke IE, Mirzaei Z, Simmons C, *Zhang XA, *Cheng HL. “Positive-contrast cellular MRI of mouse embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent,” Journal of Magnetic Resonance Imaging 2016 May 17 (Epub ahead of print)

Haedicke IE, Li T, Zhu YL, Martinez F, Hamilton AM, Murrell DH, Nofiele JT, *Cheng HL, *Scholl TJ, *Foster PJ, *Zhang XA. “An enzyme-activatable and cell-permeable Mn(III)-porphyrin as a highly efficient T(1) MRI contrast agent for cell labelling,” Chemical Science 7, 4308-4317, 2016.

Ganesh T, Estrada M, Duffin J, *Cheng HL. “T2* and T1 assessment of abdominal tissue response to graded hypoxia and hypercapnia using a controlled gas mixing circuit for small animals,” Journal of Magnetic Resonance Imaging 44(2), 305-316, 2016. 

Ganesh T, Mokhtari RB, Alhamami M, Yeger H, *Cheng HL. “Manganese-enhanced MRI of minimally gadolinium-enhancing breast tumors,” Journal of Magnetic Resonance Imaging 41(3), 806-813, 2015.

*Cheng HL, Haedicke IE, Cheng W, Nofiele JT, *Zhang XA. “Gadolinium-free T1 contrast agents for MRI: tunable pharmacokinetics of a new class of manganese porphyrins,” Journal of Magnetic Resonance Imaging 40(6), 1474-1480, 2014.

Cheng W, Haedicke IE, Nofiele J, Martinez F, Beera K, *Scholl TJ, *Cheng HL, *Zhang XA. “Complementary strategies for developing Gd-free high-field T1 MRI contrast agents based on Mn(III) porphyrins,” Journal of Medicinal Chemistry 57(2), 516-520, 2014.

Nofiele JT, Czarnota GJ, *Cheng HL. “Noninvasive manganese-enhanced magnetic resonance imaging for early detection of breast cancer metastatic potential,” Molecular Imaging 13(1), 1-10, 2014.

Nofiele JT, *Cheng HL. Ultrashort echo time for improved positive-contrast manganese-enhanced MRI of cancer. PLoS One. 2013; 8(3):e58617.

Loai Y, Ganesh T, *Cheng HL. Concurrent dual contrast for cellular magnetic resonance imaging using gadolinium oxide and iron oxide nanoparticles. Int J Mol Imaging . 2012; 2012:230942.

Loai Y, Sakib N, Janik R, Foltz WD, *Cheng HL. Human aortic endothelial cell labeling with positive contrast gadolinium oxide nanoparticles for cellular magnetic resonance imaging at 7 Tesla. Mol Imaging. 2012; 11(2):166-75.

*Cheng HL, Loai Y, Farhat WA. Monitoring tissue development in acellular matrix-based regeneration for bladder tissue engineering: multiexponential diffusion and T2* for improved specificity. NMR Biomed. 2012; 25(3):418-26.

Winter JD, St Lawrence KS, *Cheng HL. Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J Magn Reson Imaging . 2011; 34(3):608-15.

Winter JD, Estrada M, *Cheng HL. Normal tissue quantitative T1 and T2* MRI relaxation time responses to hypercapnic and hyperoxic gases. Acad Radiol . 2011; 18(9):1159-67.

Winter JD, Akens MK, *Cheng HL. Quantitative MRI assessment of VX2 tumour oxygenation changes in response to hyperoxia and hypercapnia. Phys Med Biol . 2011; 56(5):1225-42.

Kershaw LE, *Cheng HL. A general dual-bolus approach for quantitative DCE-MRI. Magn Reson Imaging . 2011; 29(2):160-6.

*Cheng HL, Islam SS, Loai Y, Antoon R, Beaumont M, Farhat WA. Quantitative magnetic resonance imaging assessment of matrix development in cell-seeded natural urinary bladder smooth muscle tissue-engineered constructs. Tissue Eng Part C Methods . 2010; 16(4):643-51.

Beaumont M, DuVal MG, Loai Y, Farhat WA, Sándor GK, *Cheng HL. Monitoring angiogenesis in soft-tissue engineered constructs for calvarium bone regeneration: an in vivo longitudinal DCE-MRI study. NMR Biomed . 2010; 23(1):48-55

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