Dennis Cvitkovitch | Professor
BSc, MSc, PhD (Manitoba)
- Faculty of Dentistry
- Institute of Biomaterials & Biomedical Engineering
Faculty of Dentistry, University of Toronto
124 Edward Street
Toronto, Ontario M5G 1G6 Canada
+1 416 979-4917 ext 4592 (office)
My research interests focus on the role of the acid tolerance response of Streptococcus mutans , the principal agent of dental caries. Using a variety of molecular biological, biochemical and in silico technologies we are also unraveling the mechanisms of cell-cell signaling and its role in biofilm formation and genetic exchange by gram positive pathogens. Ongoing collaborative programs also include the search for potential vaccine targets for Streptococcus pyogenes infections and the effects of dental restorative materials on bacterial growth and metabolism. Our work is also integrated with the University of Toronto Tissue Engineering Group focusing on the development of novel biomaterials resistant to bacterial infection.
S. Kermanshahi, J.P. Santerre, D.G. Cvitkovitch , Y. Finer. 2010. Biodegradation of Resin-Dentin Interfaces Increases Bacterial Microleakage. J Dent Res, E pub 2010/05/28
K. Krastel, D.B. Senadheera, R. Mair, J.S. Downey, S. Goodman, D.G. Cvitkovitch, 2010. Characterization of a glutamate transporter operon, glnQHMP, in Streptococcus mutans and its role in acid tolerance. J Bacteriol. 192(4): p. 984-93
Lin, A.E., K. Krastel, R. I. Hobb, S.A. Thompson, D.G. Cvitkovitch, E.C. Gaynor. 2009. Atypical roles for Campylobacter jejuni AA-ABC transporter components PaqP and PaqQ in bacterial stress tolerance and pathogen-host cell dynamics, Infect . Immun. 77(11):4912-24. Epub 2009 Aug 24.
Senadheera, D., K. Krastel, R. Mair, A. Persadmehr, J. Abranches, R. A. Burne, and D.G. Cvitkovitch. 2009. Inactivation of VicK affects acid production and acid survival of Streptococcus mutans. J. Bacteriol. 191(20):6415-24. Epub 2009 Aug 14.
Perry, J. A., D.G. Cvitkovitch and C. M. Lévesque. 2009. Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA . FEMS Microbiol Lett.; 299(2):261-6. Epub 2009 Aug 18.
formation and other virulence factors in Streptococcus mutans. J. Biomed. Mater. Res. A. 2:551-60.
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