Anne-Marie Guerguerian | Assistant Professor
MD (Montréal), PhD (Johns Hopkins), FAAP, FRCPC
- Staff Physician, Critical Care Medicine, and Senior Scientist, Neurosciences & Mental Health, Hospital for Sick Children
- Department of Paediatrics
- Interdepartmental Division of Critical Care
- Collaborative Program in Neuroscience
- Institute of Biomaterials & Biomedical Engineering
- Institute of Health Policy, Management & Evaluation
- Institute of Medical Sciences
Peter Gilgan Centre for Research and Learning
Hospital for Sick Children
686 Bay Street, 8th Floor South, 08.9709
Toronto, Ontario M5G 0A4 Canada
Guerguerian Lab (web)
Research Support Staff
Jessica Rosales, Administrative Coordinator
Judith Van Huyse, Research Manager
My program of research aims to develop the means to understand and prevent severe neurological injury in children with critical illness.
My research is focused on the developing and vulnerable brain of critically ill children and investigations specifically focus on developing the means to quantify mechanisms involved during the acute period of injury and recovery.
As we advance our knowledge of how these mechanisms are modified with brain development, severity of injury, and brain activity, and how these changes are ultimately related to functional outcomes, the ultimate goal is to define how to optimize neurological recovery.
In an attempt, to narrow the gap between preclinical models and traditional clinical trials, my lab uses clinical in vivo human experimental approaches that focus on biological signals measurable throughout the acute evolution of brain injury and recovery.
We strive to develop bedside functional neuromonitoring systems approaches somewhat like a ‘brain injury GPS’ that can be applied to children with acute evolving injury at the bedside. These in turn can be used to investigate and target detectable – not simply assumed – mechanisms evolving in the natural setting after the acute insult. These systems use a “bedside – to – computer – back to – bedside” framework in which studies involve modelling of bedside measures of neurovascular coupling, of cerebral edema or hemorrhage, of ischemia or metabolism, both in children at risk for further neurological injury or in healthy human subjects.
Ultimately the approaches pioneered in the lab can be used to merge the experimental and natural settings in more representative clinical trial designs that integrate dynamic biological signals of injury and recovery.
Eytan D, Goodwin A, Greer R, Guerguerian AM, Laussen P. Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children. Frontiers in Pediatrics, 2017 http://journal.frontiersin.org/article/10.3389/fped.2017.00052.
Moler, F.W., et al., and Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial Investigators. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. New England Journal of Medicine, 2017. 376(4): p. 318-329.
Eytan D, Pang EW, Doesburg S, Nenadovic V, Gavrilovic B, Laussen PC, Guerguerian AM. Bedside functional brain imaging in critically-ill patients using high-density EEG source modeling and multi-modal sensory stimulation. NeuroImage: Clinical. 2016 Jul;4(12):198-211.
de Caen AR, Maconochie IK, Aickin R, Atkins DL, Biarent D, Guerguerian AM, Kleinman ME, Kloeck DA, Meaney PA, Nadkarni VM, Ng KC, Nuthall G, Reis AG, Shimizu N, Tibballs J, Veliz Pintos R; Pediatric Basic Life Support and Pediatric Advanced Life Support Chapter Collaborators. Part 6: Pediatric basic life support and pediatric advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation. 2015 Oct;132(16 Suppl 1):S177-203.
Moghimi S, Schudlo L, Chau T, Guerguerian AM. Variability in prefrontal hemodynamic response during exposure to repeated self-elected music excerpts, a near-infrared spectroscopy study. Public Library of Science One. 2015 Apr;10(4):e0122148.
Lin YL, Guerguerian AM, Laussen P, Trbovich P. Heuristic Evaluation of Data Integration and Visualization Software Used for Continuous Monitoring to Support Intensive Care: A Bedside Nurse’s Perspective. 2015. J Nurs Care 4:300.
Myrden A, Kushki A, Sejdic E, Guerguerian AM, Chau T. A brain-computer interface based on bilateral transcranial Doppler ultrasound. Public Library of Science (PLoS) One. 2011 Sep 7;6(9):e24170. (8pp) Epub 2011 Sep 7.
Moghimi S, Kushki A, Guerguerian AM, Chau T. EEG-based brain-computer interfaces as access pathways for individuals with severe disabilities: the state of clinical evidence? Assistive Technology. 2013;25(2):99-110. The Official Journal of RESNA, Submission ID UATY-2011-0351.
Kotani Y, Honjo O, Davey L, Chetan D, Guerguerian AM, Gruenwald C. Evolution of technology, establishment of program, and clinical outcomes in pediatric extracorporeal membrane oxygenation: the “Sickkids” experience. Artificial Organs. 2013 Jan;37(1):21-8. DOI: 10.1111/aor.12032.
Moghimi S, Kushki A, Guerguerian AM, Chau T. Characterizing emotional response to music in the prefrontal cortex using near infrared spectroscopy. Neuroscience Letters. 2012 Sep 6;525(1):7-11.
Brady K, Lee JK, Easley B, Jallo G, Czosnyka M, Smielewski P, Shaffner DH. Guerguerian AM. Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain injury in children. Pediatrics. 2009 Dec;124(6):e1205-12.
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