Sasha M. John

Sasha John | Assistant Professor
BA (Reed), MSc (McGill), PhD (Toronto)

Main Appointments

  • Research Associate, Rotman Research Institute, Baycrest Hospital

Additional Appointments

  • Institute of Biomaterials & Biomedical Engineering

Contact Information

+1 416 785-2500, extension 3591 (office)
sasha.john@utoronto.ca (email)


Research Themes

Research Interests

Auditory Neuroscience

Biomedical engineering and understanding gained from neuroscience are applied to problems of performing Objective Audiometry in particular to Assessment of Hearing in Newborns – both in terms of clinical assessment of frequency specific hearing and also in terms of assessment of more real-world sounds. Emphasis is placed on increasing, speed, accuracy, and flexibility of testing methods.

Multiple Auditory Steady-State Response (MASTER) Tests: MASTER technology was developed largely due to a collaboration between Dr. Terry Picton and Dr. Sasha John. Dr Picton serves first as Sasha’s graduate advisor and then as a collaborator over a 10 year period which has produced over 20 publications relating to various type of statistical tests, signal-processing algorithms. testing techniques, and auditory stimuli (see http://www.mastersystem.ca). Other collaborators include Drs. Andrew Dimitrijevic, Bob Burkhard, Claude Allain; David Purcell, Hilmi Djani, Karolina Kluk, and Otavio Lins. MASTER technology is now available in FDA approved devices distributed by Bio-logic Systems Corporation, a division of Natus Inc.http://www.natus.com/index.cfm?page=company_1&crid=8&contentid=3

Deep Brain Sensing and Stimulation

Dr. John has conducted biomedical engineering research and development activity in areas of electrical and pharmaceutical neurostimulation and associated development of algorithms and technologies. Dr. John is an inventor or co-inventor on over 15 patent applications in this area, some of which were developed as a consultant to medical device companies developing new types of neurostimulators.

Cardiac Physiological Monitoring

Dr. John has conducted biomedical engineering research and development activity in areas of real-time ischemia monitoring and associated development of algorithms and technologies. Dr. John is an inventor or co-inventor on over 12 patent applications in this area, some of which were developed as a consultant to medical device companies developing new types of implantable cardiac monitors.

Select Publications

Hopenfeld B, John MS, Fischell TA, Johnson SR. A statistically based acute ischemia detection algorithm suitable for an implantable device. Ann Biomed Eng. 2012 Dec;40(12):2627-38.

Choi JM, Purcell DW, John MS. Phase stability of auditory steady state responses in newborn infants. Ear Hear. 2011 Sep-Oct;32(5):593-604.

Fischell TA, Fischell DR, Avezum A, John MS, Holmes D, Foster M 3rd, Kovach R, Medeiros P, Piegas L, Guimaraes H, Gibson CM. Initial clinical results using intracardiac electrogram monitoring to detect and alert patients during coronary plaque rupture and ischemia. J Am Coll Cardiol. 2010 Sep 28;56(14):1089-98.

Purcell DW, John MS. Evaluating the modulation transfer function of auditory steady state responses in the 65 Hz to 120 Hz range. Ear Hear. 2010 Oct;31(5):667-78.

Picton TW, van Roon P, John MS. Multiple auditory steady state responses (80-101 Hz): effects of ear, gender, handedness, intensity and modulation rate. Ear Hear. 2009 Feb;30(1):100-9.

Hopenfeld, B., John, M.S., Fischell, D.R., Medeiros, P., Guimarães, H.P., Piegas, L.S., The Guardian: an implantable system for chronic ambulatory monitoring of acute myocardial infarction. J Electrocardiol. 2009 Nov-Dec;42(6):481-6.

John, M.S., Purcell, D.W. (2008) Technical Principles of Auditory Steady-State Response Testing. In G Rance (ed.) Auditory Steady-State Response: Generation Recording, and Clinical Applications. Plural Publishing, Chapter 2, pages: 11-54.

Picton, T.W., Van Roon, P., John M.S., Human Auditory Steady-State Responses During Sweeps of Intensity, Ear and Hearing; 28(4):542-57. 2007.

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