Joshua N. Milstein

Joshua Milstein | Assistant Professor
BS (Northern Illinois), PhD (Colorado)

Main Appointments

  • Department of Chemical & Physical Sciences, University of Toronto Mississauga (UTM)
  • Department of Physics

Additional Appointments

  • Institute of Biomaterials & Biomedical Engineering

Contact Information

University of Toronto Mississauga
Davis Building , 3359 Mississauga Road North, Room 4053
Mississauga, Ontario L5L 1C6 Canada

+1 905 569-4598 (office) (email)
Milstein Laboratory for Biological Physics (web)

Research Themes

Research Interests

My research focuses on understanding the biomechanical and dynamical properties of DNA, which, while being intimately involved in genetic function, have operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on.

Our laboratory develops and employs a variety of single-molecule biophysical techniques from optical tweezers, which allow us to manipulate individual biomolecules, to super-resolution microscopes, for observing cellular dynamics in bacteria. The research is highly interdisciplinary by nature, bringing quantitative efforts to bear on problems within the medical and life sciences, with a range of implications for our understanding of health and disease.

Select Publications

Wang H, Yehoshua S, Ali SS, Navarre WW, Milstein JN. A biomechanical mechanism for initiating DNA packaging. Nucleic Acids Res. 2014 Oct 1. pii: gku896. [Epub ahead of print] PubMed PMID: 25274732.

See current publications at PubMed