Arthur S. Slutsky

Arthur Slutsky | Professor
BASc (Toronto), MD (McMaster), MASc (Toronto), FCAHS, FRSC

Main Appointments

  • Division of Respirology, Department of Medicine
  • Scientist, Keenan Research Centre for Biomedical Science & Vice President, Research, St. Michael’s Hospital

Additional Appointments

  • Institute of Biomaterials & Biomedical Engineering
  • Chair, Clinical Trials Ontario

Contact Information

416-864-5637 (office) (email)

Research Themes

Engineering in a Clinical Setting

Research Areas

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI).

Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma.

My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models.

As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Select Publications

Razak, F, Corsi, DJ, Slutsky, AS, Kurpad, A, Berkman, L, Laupacis, A et al.. Prevalence of Body Mass Index Lower Than 16 Among Women in Low- and Middle-Income Countries. JAMA. 2015;314 (20):2164-71. doi: 10.1001/jama.2015.15666. PubMed PMID:26599184 .

Serpa Neto, A, Schultz, MJ, Slutsky, AS. Current concepts of protective ventilation during general anaesthesia. Swiss Med Wkly. 2015;145 :w14211. Epub 2015/11/12. doi: 10.4414/smw.2015.14211. PubMed PMID:26561993 .

Fanelli, V, Morita, Y, Cappello, P, Ghazarian, M, Sugumar, B, Delsedime, L et al.. Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1. Anesthesiology. 2015; :. doi: 10.1097/ALN.0000000000000907. PubMed PMID:26540149 .

Tabuchi, A, Nickles, HT, Kim, M, Semple, JW, Koch, E, Brochard, L et al.. Acute Lung Injury Causes Asynchronous Alveolar Ventilation Which Can Be Corrected by Individual Sighs. Am. J. Respir. Crit. Care Med. 2015; :. doi: 10.1164/rccm.201505-0901OC. PubMed PMID:26513710 .

Steinberg, BE, Goldenberg, NM, Fairn, GD, Kuebler, WM, Slutsky, AS, Lee, WL et al.. Is basic science disappearing from medicine? The decline of biomedical research in the medical literature. FASEB J. 2015; :. doi: 10.1096/fj.15-281758. PubMed PMID:26467794 .

Curley, GF, Laffy, JG, Zhang, H, Slutsky, AS. Noninvasive respiratory support for acute respiratory failure-high flow nasal cannula oxygen or non-invasive ventilation?. J Thorac Dis. 2015;7 (7):1092-7. doi: 10.3978/j.issn.2072-1439.2015.07.18. PubMed PMID:26380720 PubMed Central PMC4522497.

Liu, L, Takahashi, D, Qui, H, Slutsky, AS, Sinderby, C, Beck, J et al.. Feasibility of neurally adjusted positive end-expiratory pressure in rabbits with early experimental lung injury. BMC Anesthesiol. 2015;15 :124. doi: 10.1186/s12871-015-0103-z. PubMed PMID:26369672 PubMed Central PMC4570554.

Cabrera-Benítez, NE, Valladares, F, García-Hernández, S, Ramos-Nuez, Á, Martín-Barrasa, JL, Martínez-Saavedra, MT et al.. Altered Profile of Circulating Endothelial-Derived Microparticles in Ventilator-Induced Lung Injury. Crit. Care Med. 2015;43 (12):e551-9. doi: 10.1097/CCM.0000000000001280. PubMed PMID:26308427 .

Godet, T, Combes, A, Zogheib, E, Jabaudon, M, Futier, E, Slutsky, AS et al.. Novel CO2 removal device driven by a renal-replacement system without hemofilter. A first step experimental validation. Anaesth Crit Care Pain Med. 2015;34 (3):135-40. doi: 10.1016/j.accpm.2014.08.006. PubMed PMID:26004872 .

Costa, EL, Slutsky, AS, Amato, MB. Driving pressure as a key ventilation variable. N. Engl. J. Med. 2015;372 (21):2072. doi: 10.1056/NEJMc1503487. PubMed PMID:25992757 .

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