Christopher Yip | Professor
BASc (Toronto), PhD (Minnesota), FAAAS, FEIC, PEng
- Associate Vice-President, International Partnerships
- Department of Chemical Engineering & Applied Chemistry
- Institute of Biomaterials & Biomedical Engineering
- Department of Biochemistry
- Donnelly Centre for Cellular & Biomolecular Research
Office of the Associate Vice-President
Simcoe Hall, 27 King’s College Circle, Room 109C
+1 416 978-0888 (office)
Lidy Lee, Administrative Coordinator & Executive Assistant
Simcoe Hall, 27 King’s College Circle, Suite 216
+1 416 978-0225 (office)
Donnelly Centre (DC), 160 College Street, Room 404
+1 416 978-7853 (office)
Yip Lab for Studies in Single Molecule Biophysics (web)
Molecular self-assembly focusing on protein-ligand and biomolecular complexes and elucidation of the mechanisms associated with the development of solution and solid-state structure and molecular conformation. Study of biomolecular association and ligand-receptor interactions using oriented molecular arrays at interfaces. Application of scanning probe microscopy to the characterization of biomolecular processes and structures.
Direct elucidation of the mechanisms governing molecular self-assembly has clear implications for understanding and possibly controlling processes ranging from the crystallization of biomolecules and pharmaceutics to the formation of protein complexes and the interaction of protein and drug molecules with cellular membranes and biomimetic substrates.
The ability to acquire in situ real-space information would thus represent a significant advance towards understanding the kinetics and mechanics of molecular self-assembly.
Our research program focuses on the application of in situ scanning probe microscopy in combination with other biophysical characterization techniques including circular dichroism, light scattering, X-ray scattering, NMR spectroscopy, and infrared and Raman spectroscopy to the study of self-assembled systems ranging from molecular and protein crystallization to the formation of ligand complexes and direct measurement of intermolecular forces.
Collaborations with structural biology and crystallography research groups at the University of Toronto in additional to external programs with pharmaceutical companies offer the opportunity to study a wide variety of biomolecular phenomena and processes of therapeutic interest.
Forces of Interactions between Bare and Polymer-Coated Iron and Silica: Effect of pH, Ionic Strength, and Humic Acids. Pensini E, Sleep BE, Yip CM, O’Carroll D. Environ Sci Technol. 2012 Dec 18. 46(24):13401-8.
Correlative optical and scanning probe microscopies for mapping interactions at membranes.
Yip CM. Methods Mol Biol. 2013. 950:439-56.
Effect of water chemistry and aging on iron-mica interaction forces: Implications for iron particle transport. Pensini E, Yip CM, O’Carroll DM, Sleep BE. Langmuir. 2012 Jul 17. 28(28):10453-63.
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. Yin LM, Edwards MA, Li J, Yip CM, Deber CM. J Biol Chem. 2012 Mar 2. 287(10):7738-45.
Charge Carrier Mobility In Fluorinated Phenoxy Boron Subphthalocyanines: The Role Of Solid State Packing. Jeffrey S. Castrucci, Michael G. Helander, Graham E. Morse, Zheng-Hong Lu, Christopher M. Yip, and Timothy P. Bender. Crystal Growth & Design 2012 12 (3), 1095-1100.
Solution Phase Synthesis Of Carbon Quantum Dots As Sensitizers For Nanocrystalline Tio2 Solar Cells. Mirtchev P, Henderson EJ, Soheilnia N, Yip CM, Geoffrey OA. Journal of Materials Chemistry. 2012 Jan 28. 22: 1265-1269.
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