Peter Zandstra

Peter Zandstra

Peter Zandstra | University Professor & Canada Research Chair, Stem Cell Bioengineering

Main Appointments

Additional Appointments

  • Department of Chemical Engineering & Applied Chemistry
  • Donnelly Centre for Cellular & Biomolecular Research (CCBR)

Contact Information

Office: CCBR, 160 College Street, Room 1116

+1 416 978-8888 (office) (email)
Zandstra Lab for Stem Cell Bioengineering (web)

Research Themes

Research Interests

Dr. Zandstra’s work integrates engineering and biological approaches and has contributed to the development of clinically and industrially relevant and academically recognized technologies based on the design of bioprocesses for the growth and differentiation of adult and embryonic stem cells. Direct applications of this work include tissue and cellular engineering, gene therapy, and organ transplantation.

Select Publications

PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions. Qiao W, Quon G, Csaszar E, Yu M, Morris Q, Zandstra PW.  PLoS Comput Biol. 2012 Dec. 8(12):e1002838.

High density continuous production of murine pluripotent cells in an acoustic perfused bioreactor at different oxygen concentrations. Baptista RP, Fluri DA, Zandstra PW.  Biotechnol Bioeng. 2012 Sep 4.

Microenvironment-mediated reversion of epiblast stem cells by reactivation of repressed JAK-STAT signaling. Onishi K, Tonge PD, Nagy A, Zandstra PW.  Integr Biol (Camb). 2012 Sep 18.

Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures. Fluri DA, Tonge PD, Song H, Baptista RP, Shakiba N, Shukla S, Clarke G, Nagy A, Zandstra PW.  Nat Methods. 2012 Mar 25. 9(5):509-16.

Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation. Woodford C, Zandstra PW.  Curr Opin Biotechnol. 2012 Mar 21.

Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells. Moledina F, Clarke G, Oskooei A, Onishi K, Günther A, Zandstra PW.  Proc Natl Acad Sci U S A. 2012 Feb 14.

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics. Ungrin MD, Clarke G, Yin T, Niebrugge S, Nostro MC, Sarangi F, Wood G, Keller G, Zandstra PW.  Biotechnol Bioeng. 2012 Apr. 109(4):853-66.

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